A1 Refereed original research article in a scientific journal
Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica
Authors: Dmitry Yu. Murzin, Teemu Heikkilä
Publisher: TAYLOR & FRANCIS INC
Publishing place: PHILADELPHIA; 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
Publication year: 2014
Journal: Chemical Engineering Communications
Journal name in source: Chemical Engineering Communications
Journal acronym: Chem.Eng.Commun.
Volume: 201
Issue: 5
First page : 579
Last page: 592
Number of pages: 14
ISSN: 0098-6445
DOI: https://doi.org/10.1080/00986445.2013.782290
Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treating dissolution data with sigmoid behavior.
Keywords:
DELIVERY, DIFFUSION, Drug delivery, FORMULATION, HETEROGENEITY, Indomethacin, IN-VIVO CORRELATION, Kinetics, MICROSPHERES, Ordered mesoporous silica, POLYMERS, SBA-15, Sigmoid behavior, SOLUBLE DRUGS, SOLUTE RELEASE
