A1 Refereed original research article in a scientific journal

Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica



Authors: Dmitry Yu. Murzin, Teemu Heikkilä

Publisher: TAYLOR & FRANCIS INC

Publishing place: PHILADELPHIA; 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA

Publication year: 2014

Journal: Chemical Engineering Communications

Journal name in source: Chemical Engineering Communications

Journal acronym: Chem.Eng.Commun.

Volume: 201

Issue: 5

First page : 579

Last page: 592

Number of pages: 14

ISSN: 0098-6445

DOI: https://doi.org/10.1080/00986445.2013.782290


Abstract

Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treating dissolution data with sigmoid behavior.




Last updated on 2024-26-11 at 21:04