Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica - UTU Tutkimustietojärjestelmä

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Modeling of Drug Dissolution Kinetics with Sigmoidal Behavior from Ordered Mesoporous Silica

Tekijät: Dmitry Yu. Murzin, Teemu Heikkilä

Kustantaja: TAYLOR & FRANCIS INC

Kustannuspaikka: PHILADELPHIA; 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA

Julkaisuvuosi: 2014

Journal: Chemical Engineering Communications

Tietokannassa oleva lehden nimi: Chemical Engineering Communications

Lehden akronyymi: Chem.Eng.Commun.

Vuosikerta: 201

Numero: 5

Aloitussivu: 579

Lopetussivu: 592

Sivujen määrä: 14

ISSN: 0098-6445

DOI: https://doi.org/10.1080/00986445.2013.782290

Tiivistelmä

Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treating dissolution data with sigmoid behavior.