6-[18F]Fluoro-l-DOPA Uptake in the Rat Pancreas is Dependent on the Tracer Metabolism




Kalliokoski T, Tuomela J, Haavisto L, Forsback S, Snellman A, Helin S, Gronroos TJ, Solin O, Haaparanta-Solin M

PublisherSPRINGER

2014

Molecular Imaging and Biology

MOLECULAR IMAGING AND BIOLOGY

MOL IMAGING BIOL

16

3

403

411

9

1536-1632

DOIhttps://doi.org/10.1007/s11307-013-0701-4(external)



Altering the metabolism of [F-18]FDOPA by using various enzymatic inhibitors increased the radioactivity uptake and changed the radiometabolic profile in the pancreas allowing better discrimination between pancreas and surrounding tissues of rat. However, these manipulations did not separate islets from the exocrine pancreas. Elucidating the metabolic behavior of [F-18]FDOPA provides a biochemical foundation of PET imaging of the rat pancreas.



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