6-[18F]Fluoro-l-DOPA Uptake in the Rat Pancreas is Dependent on the Tracer Metabolism
: Kalliokoski T, Tuomela J, Haavisto L, Forsback S, Snellman A, Helin S, Gronroos TJ, Solin O, Haaparanta-Solin M
Publisher: SPRINGER
: 2014
: Molecular Imaging and Biology
: MOLECULAR IMAGING AND BIOLOGY
: MOL IMAGING BIOL
: 16
: 3
: 403
: 411
: 9
: 1536-1632
DOI: https://doi.org/10.1007/s11307-013-0701-4(external)
Altering the metabolism of [F-18]FDOPA by using various enzymatic inhibitors increased the radioactivity uptake and changed the radiometabolic profile in the pancreas allowing better discrimination between pancreas and surrounding tissues of rat. However, these manipulations did not separate islets from the exocrine pancreas. Elucidating the metabolic behavior of [F-18]FDOPA provides a biochemical foundation of PET imaging of the rat pancreas.