6-[18F]Fluoro-l-DOPA Uptake in the Rat Pancreas is Dependent on the Tracer Metabolism - UTU Research Portal

A1 Refereed original research article in a scientific journal

6-[18F]Fluoro-l-DOPA Uptake in the Rat Pancreas is Dependent on the Tracer Metabolism

Authors: Kalliokoski T, Tuomela J, Haavisto L, Forsback S, Snellman A, Helin S, Gronroos TJ, Solin O, Haaparanta-Solin M

Publisher: SPRINGER

Publication year: 2014

Journal: Molecular Imaging and Biology

Journal name in source: MOLECULAR IMAGING AND BIOLOGY

Journal acronym: MOL IMAGING BIOL

Volume: 16

Issue: 3

First page : 403

Last page: 411

Number of pages: 9

ISSN: 1536-1632

DOI: https://doi.org/10.1007/s11307-013-0701-4

Abstract

Altering the metabolism of [F-18]FDOPA by using various enzymatic inhibitors increased the radioactivity uptake and changed the radiometabolic profile in the pancreas allowing better discrimination between pancreas and surrounding tissues of rat. However, these manipulations did not separate islets from the exocrine pancreas. Elucidating the metabolic behavior of [F-18]FDOPA provides a biochemical foundation of PET imaging of the rat pancreas.