A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
From Vessel Sprouting to Normalization Role of the Prolyl Hydroxylase Domain Protein/Hypoxia-Inducible Factor Oxygen-Sensing Machinery
Tekijät: Coulon C, Georgiadou M, Roncal C, De Bock K, Langenberg T, Carmeliet P
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2010
Lehti: Arteriosclerosis, Thrombosis, and Vascular Biology
Tietokannassa oleva lehden nimi: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Lehden akronyymi: ARTERIOSCL THROM VAS
Vuosikerta: 30
Numero: 12
Aloitussivu: 2331
Lopetussivu: 2336
Sivujen määrä: 6
ISSN: 1079-5642
DOI: https://doi.org/10.1161/ATVBAHA.110.214106
Tiivistelmä
The accepted model of vessel branching distinguishes several endothelial cell fates. At the forefront of a vessel sprout, "tip cells" guide the sprouting vessel toward an angiogenic stimulus. Behind the tip, "stalk cells" proliferate to elongate the vessel branch and create a lumen. In mature vessels, endothelial cells acquire a streamlined shape to optimally conduct blood flow. For this purpose, endothelial cells switch to the "phalanx" cell fate, which is characterized by quiescent and nonproliferating cells aligned in a tight cobblestonelike layer. Vessel maturation also requires the recruitment of mural cells (ie, smooth muscle cells and pericytes). These cell fates are often altered in pathological conditions, most prominently during the formation of tumor vasculature. Given the essential role of hypoxia as the driving force for initiating angiogenesis, it is not surprising that the hypoxia-sensing machinery controls key steps in physiological and pathological angiogenesis. (Arterioscler Thromb Vasc Biol. 2010;30:2331-2336.)
The accepted model of vessel branching distinguishes several endothelial cell fates. At the forefront of a vessel sprout, "tip cells" guide the sprouting vessel toward an angiogenic stimulus. Behind the tip, "stalk cells" proliferate to elongate the vessel branch and create a lumen. In mature vessels, endothelial cells acquire a streamlined shape to optimally conduct blood flow. For this purpose, endothelial cells switch to the "phalanx" cell fate, which is characterized by quiescent and nonproliferating cells aligned in a tight cobblestonelike layer. Vessel maturation also requires the recruitment of mural cells (ie, smooth muscle cells and pericytes). These cell fates are often altered in pathological conditions, most prominently during the formation of tumor vasculature. Given the essential role of hypoxia as the driving force for initiating angiogenesis, it is not surprising that the hypoxia-sensing machinery controls key steps in physiological and pathological angiogenesis. (Arterioscler Thromb Vasc Biol. 2010;30:2331-2336.)
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