Association of tumour necrosis factor a, b and c microsatellite polymorphisms with clinical disease activity and induction of remission in early rheumatoid arthritis



: Laivoranta-Nyman S, Mottonen T, Hannonen P, Korpela M, Kautlainen H, Leirisalo-Repo M, Julkunen H, Luukkainen R, Hakala M, Vuori K, Laine AP, Toivanen A, Ilonen J

Publisher: CLINICAL & EXPER RHEUMATOLOGY CLINICAL & EXPER RHEUMATOLOGY

: 2006

: Clinical and Experimental Rheumatology

: Association of tumour necrosis factor a, b and c microsatellite polymorphisms with clinical disease activity and induction of remission in early rheumatoid arthritis

: CLIN EXP RHEUMATOL

: 24

: 6

: 636

: 642

: 7

: 0392-856X


Conclusion: Early TNFb1+ RA patients have more active disease but respond more favourably to COMBI treatment than the patients without this microsatellite allele. The finding may be of clinical relevance for the choice of DMARDs in early RA.



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