A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging
Tekijät: Dickens AM, Yoo SW, Chin AC, Xu JD, Johnson TP, Trout AL, Hauser KF, Haughey NJ
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2017
Journal: Scientific Reports
Tietokannassa oleva lehden nimi: SCIENTIFIC REPORTS
Lehden akronyymi: SCI REP-UK
Artikkelin numero: ARTN 7748
Vuosikerta: 7
Sivujen määrä: 11
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-017-07570-5
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/Publication/33562946
The widespread use of combinational antiretroviral therapies (cART) in developed countries has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost universally fatal disease to a chronic infection for the majority of individuals. Although cART has reduced the severity of neurological damage in HIV-infected individuals, the likelihood of cognitive impairment increases with age, and duration of infection. As cART does not suppress the expression of HIV non-structural proteins, it has been proposed that a constitutive production of HIV regulatory proteins in infected brain cells may contribute to neurological damage. However, this assumption has never been experimentally tested. Here we take advantage of the leaky tetracycline promoter system in the Tat-transgenic mouse to show that a chronic very low-level expression of Tat is associated with astrocyte activation, inflammatory cytokine expression, ceramide accumulation, reductions in brain volume, synaptic, and axonal damage that occurs over a time frame of 1 year. These data suggest that a chronic low-level production of Tat may contribute to progressive neurological damage in virally suppressed HIV-infected individuals.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
