Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice Genome-Wide Promoter Methylation Study - UTU Tutkimustietojärjestelmä

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Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice Genome-Wide Promoter Methylation Study

Tekijät: Babu M, Devi TD, Makinen P, Kaikkonen M, Lesch HP, Junttila S, Laiho A, Ghimire B, Gyenesei A, Yla-Herttuala S

Kustantaja: LIPPINCOTT WILLIAMS & WILKINS

Julkaisuvuosi: 2015

Journal: Circulation Research

Tietokannassa oleva lehden nimi: CIRCULATION RESEARCH

Lehden akronyymi: CIRC RES

Vuosikerta: 117

Numero: 3

Aloitussivu: 289

Lopetussivu: 299

Sivujen määrä: 11

ISSN: 0009-7330

DOI: https://doi.org/10.1161/CIRCRESAHA.115.306424

Tiivistelmä

Conclusions: We found significant promoter hypomethylation of genes typical for proinflammatory M1-M phi s and hypermethylation of anti-inflammatory, proangiogenic M2-M phi genes in hyperlipidemia and T2DM ischemic muscles. Epigenetic alterations modify M phi phenotype toward proinflammatory M1 as opposed to anti-inflammatory, proangiogenic, and tissue repair M2 phenotype, which may contribute to the impaired adaptive vascular growth under these pathological conditions.