Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice Genome-Wide Promoter Methylation Study - UTU Research Portal

A1 Refereed original research article in a scientific journal

Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice Genome-Wide Promoter Methylation Study

Authors: Babu M, Devi TD, Makinen P, Kaikkonen M, Lesch HP, Junttila S, Laiho A, Ghimire B, Gyenesei A, Yla-Herttuala S

Publisher: LIPPINCOTT WILLIAMS & WILKINS

Publication year: 2015

Journal: Circulation Research

Journal name in source: CIRCULATION RESEARCH

Journal acronym: CIRC RES

Volume: 117

Issue: 3

First page : 289

Last page: 299

Number of pages: 11

ISSN: 0009-7330

DOI: https://doi.org/10.1161/CIRCRESAHA.115.306424(external)

Abstract

Conclusions: We found significant promoter hypomethylation of genes typical for proinflammatory M1-M phi s and hypermethylation of anti-inflammatory, proangiogenic M2-M phi genes in hyperlipidemia and T2DM ischemic muscles. Epigenetic alterations modify M phi phenotype toward proinflammatory M1 as opposed to anti-inflammatory, proangiogenic, and tissue repair M2 phenotype, which may contribute to the impaired adaptive vascular growth under these pathological conditions.