A1 Refereed original research article in a scientific journal

1-ALKYLTHIOALKYLATION OF NUCLEOSIDE HYDROXYL FUNCTIONS AND ITS SYNTHETIC APPLICATIONS - A NEW VERSATILE METHOD IN NUCLEOSIDE CHEMISTRY



Authors: ZAVGORODNY S, POLIANSKI M, BESIDSKY E, KRIUKOV V, SANIN A, POKROVSKAYA M, GURSKAYA G, LONNBERG H, AZHAYEV A

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Publication year: 1991

Journal:: Tetrahedron Letters

Journal name in source: TETRAHEDRON LETTERS

Journal acronym: TETRAHEDRON LETT

Volume: 32

Issue: 51

First page : 7593

Last page: 7596

Number of pages: 4

ISSN: 0040-4039

DOI: https://doi.org/10.1016/0040-4039(91)80543-F


Abstract
Treatment of appropriately protected nucleosides with a mixture of acetic acid, acetic anhydride and dialkylsulfoxide was shown to give O-(1-alkylthioalkylated) nucleosides that were oxidized to the corresponding sulfoxides and sulfones, or converted via O-halogenomethyl derivatives to various O-substituted nucleosides.


Research Areas



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