A1 Refereed original research article in a scientific journal
Epitope Specificity and IgG Subclass Distribution of Autoantibodies to Cardiac Troponin
Authors: Savukoski T, Twarda A, Hellberg S, Ristiniemi N, Wittfooth S, Sinisalo J, Pettersson K
Publisher: AMER ASSOC CLINICAL CHEMISTRY
Publication year: 2013
Journal: Clinical Chemistry
Journal name in source: CLINICAL CHEMISTRY
Journal acronym: CLIN CHEM
Number in series: 3
Volume: 59
Issue: 3
First page : 512
Last page: 518
Number of pages: 7
ISSN: 0009-9147
DOI: https://doi.org/10.1373/clinchem.2012.194860
Abstract
CONCLUSIONS: IgG subclass studies confirm that cTnAAb formation may be triggered/boosted in acute cardiac events. This new information about the epitope specificity of cTnAAbs should be used to reevaluate existing recommendations regarding use of midfragment epitopes in cTnI assays. To circumvent the negative interference of the highly heterogeneous cTnAAbs, use of 3 or more unconventionally selected epitopes should be considered. (C) 2012 American Association for Clinical Chemistry
CONCLUSIONS: IgG subclass studies confirm that cTnAAb formation may be triggered/boosted in acute cardiac events. This new information about the epitope specificity of cTnAAbs should be used to reevaluate existing recommendations regarding use of midfragment epitopes in cTnI assays. To circumvent the negative interference of the highly heterogeneous cTnAAbs, use of 3 or more unconventionally selected epitopes should be considered. (C) 2012 American Association for Clinical Chemistry
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