A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Epitope Specificity and IgG Subclass Distribution of Autoantibodies to Cardiac Troponin
Tekijät: Savukoski T, Twarda A, Hellberg S, Ristiniemi N, Wittfooth S, Sinisalo J, Pettersson K
Kustantaja: AMER ASSOC CLINICAL CHEMISTRY
Julkaisuvuosi: 2013
Journal: Clinical Chemistry
Tietokannassa oleva lehden nimi: CLINICAL CHEMISTRY
Lehden akronyymi: CLIN CHEM
Numero sarjassa: 3
Vuosikerta: 59
Numero: 3
Aloitussivu: 512
Lopetussivu: 518
Sivujen määrä: 7
ISSN: 0009-9147
DOI: https://doi.org/10.1373/clinchem.2012.194860
Tiivistelmä
CONCLUSIONS: IgG subclass studies confirm that cTnAAb formation may be triggered/boosted in acute cardiac events. This new information about the epitope specificity of cTnAAbs should be used to reevaluate existing recommendations regarding use of midfragment epitopes in cTnI assays. To circumvent the negative interference of the highly heterogeneous cTnAAbs, use of 3 or more unconventionally selected epitopes should be considered. (C) 2012 American Association for Clinical Chemistry
CONCLUSIONS: IgG subclass studies confirm that cTnAAb formation may be triggered/boosted in acute cardiac events. This new information about the epitope specificity of cTnAAbs should be used to reevaluate existing recommendations regarding use of midfragment epitopes in cTnI assays. To circumvent the negative interference of the highly heterogeneous cTnAAbs, use of 3 or more unconventionally selected epitopes should be considered. (C) 2012 American Association for Clinical Chemistry
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