Global Distribution of Human Protoparvoviruses



: Elina Väisänen, Ushanandini Mohanraj, Paula M. Kinnunen1, Pikka Jokelainen, Haider Al-Hello, Ali M. Barakat, Mohammadreza Sadeghi, Farid A. Jalilian, Amir Majlesi, Moses Masika, Dufton Mwaengo, Omu Anzala, Eric Delwart, Olli Vapalahti, Klaus Hedman, Maria Söderlund-Venermo

Publisher: CENTERS DISEASE CONTROL

: 2018

: Emerging Infectious Diseases

: EMERGING INFECTIOUS DISEASES

: EMERG INFECT DIS

: 24

: 7

: 1292

: 1299

: 8

: 1080-6040

DOI: https://doi.org/10.3201/eid2407.172128

: https://wwwnc.cdc.gov/eid/article/24/7/17-2128_article

: https://research.utu.fi/converis/portal/detail/Publication/32503927


Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been detected in feces of children with diarrhea. In addition, cutavirus has been detected in skin biopsy specimens of cutaneous T-cell lymphoma patients in France and in 1 melanoma patient in Denmark. We studied seroprevalences of IgG against bufavirus, tusavirus, and cutavirus in various populations (n = 840), and found a striking geographic difference in prevalence of bufavirus IgG. Although prevalence was low in adult populations in Finland (1.9%) and the United States (3.6%), bufavirus IgG was highly prevalent in populations in Iraq (84.8%), Iran (56.1%), and Kenya (72.3%). Conversely, cutavirus IgG showed evenly low prevalences (0%-5.6%) in all cohorts, and tusavirus IgG was not detected. These results provide new insights on the global distribution and endemic areas of protoparvoviruses.

Last updated on 2024-26-11 at 23:22