A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Repositioning Microtubule Stabilizing Drugs for Brain Disorders
Tekijät: Varidaki A, Hong Y, Coffey ET
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2018
Journal: Frontiers in Cellular Neuroscience
Tietokannassa oleva lehden nimi: FRONTIERS IN CELLULAR NEUROSCIENCE
Lehden akronyymi: FRONT CELL NEUROSCI
Artikkelin numero: ARTN 226
Vuosikerta: 12
Sivujen määrä: 15
ISSN: 1662-5102
eISSN: 1662-5102
DOI: https://doi.org/10.3389/fncel.2018.00226
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/32174510
Microtubule stabilizing agents are among the most clinically useful chemotherapeutic drugs. Mostly, they act to stabilize microtubules and inhibit cell division. While not without side effects, new generations of these compounds display improved pharmacokinetic properties and brain penetrance. Neurological disorders are intrinsically associated with microtubule defects, and efforts to reposition microtubule-targeting chemotherapeutic agents for treatment of neurodegenerative and psychiatric illnesses are underway. Here we catalog microtubule regulators that are associated with Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, schizophrenia and mood disorders. We outline the classes of microtubule stabilizing agents used for cancer treatment, their brain penetrance properties and neuropathy side effects, and describe efforts to apply these agents for treatment of brain disorders. Finally, we summarize the current state of clinical trials for microtubule stabilizing agents under evaluation for central nervous system disorders.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
