Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia - UTU Research Portal

A1 Refereed original research article in a scientific journal

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

Authors: Koistinen V, Karna R, Koistinen A, Arjonen A, Tammi M, Rilla K

Publisher: ELSEVIER INC

Publication year: 2015

Journal: Experimental Cell Research

Journal name in source: EXPERIMENTAL CELL RESEARCH

Journal acronym: EXP CELL RES

Volume: 337

Issue: 2

First page : 179

Last page: 191

Number of pages: 13

ISSN: 0014-4827

DOI: https://doi.org/10.1016/j.yexcr.2015.06.016

Abstract

The results of this work suggest that protrusions similar to those of HAS3 overexpressing cells in vitro exist also in cells with active hyaluronan synthesis in vivo. These protrusions are similar to common filopodia but are independent of substratum attachment due to the extracellular scaffolding by the hyaluronan coat that accounts for the growth and maintenance of these structures, previously associated to invasion, adhesion and multidrug resistance. (C) 2015 Elsevier Inc. All rights reserved.