Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia - UTU Tutkimustietojärjestelmä

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Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

Tekijät: Koistinen V, Karna R, Koistinen A, Arjonen A, Tammi M, Rilla K

Kustantaja: ELSEVIER INC

Julkaisuvuosi: 2015

Journal: Experimental Cell Research

Tietokannassa oleva lehden nimi: EXPERIMENTAL CELL RESEARCH

Lehden akronyymi: EXP CELL RES

Vuosikerta: 337

Numero: 2

Aloitussivu: 179

Lopetussivu: 191

Sivujen määrä: 13

ISSN: 0014-4827

DOI: https://doi.org/10.1016/j.yexcr.2015.06.016

Tiivistelmä

The results of this work suggest that protrusions similar to those of HAS3 overexpressing cells in vitro exist also in cells with active hyaluronan synthesis in vivo. These protrusions are similar to common filopodia but are independent of substratum attachment due to the extracellular scaffolding by the hyaluronan coat that accounts for the growth and maintenance of these structures, previously associated to invasion, adhesion and multidrug resistance. (C) 2015 Elsevier Inc. All rights reserved.