A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity
Tekijät: Laakso S, Viljakainen H, Lipsanen-Nyman M, Turpeinen U, Ivaska KK, Anand-Ivell R, Ivell R, Mäkitie O
Kustantaja: S. Karger AG
Julkaisuvuosi: 2018
Lehti:Hormone Research in Paediatrics
Tietokannassa oleva lehden nimiHormone Research in Paediatrics
Vuosikerta: 89
Numero: 6
Aloitussivu: 442
Lopetussivu: 449
Sivujen määrä: 8
ISSN: 1663-2818
DOI: https://doi.org/10.1159/000489818
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/32042681
BACKGROUND:
Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes, and skeleton at late puberty.
METHODS:
A cohort of adolescent and young adult males with severe childhood-onset obesity (n = 21, mean age 18.5 years) and an age-matched control group were assessed for testicular hormones and X-ray absorptiometry-derived bone mass.
RESULTS:
Current median body mass indexes for the obese and control subjects were 37.4 and 22.9. Severe early-onset obesity manifested with lower free testosterone (median [interquartile range] 244 [194-332] vs. 403 [293-463] pmol/L, p = 0.002). Lower insulin-like 3 (1.02 [0.82-1.23] vs. 1.22 [1.01-1.46] ng/mL, p = 0.045) and lower ratio of testosterone to luteinizing hormone (2.81 [1.96-3.98] vs. 4.10 [3.03-5.83] nmol/IU, p = 0.008) suggested disrupted Leydig cell function. The degree of current obesity inversely correlated with free testosterone (τ = -0.516, p = 0.003), which in turn correlated positively with bone area at all measurement sites in males with childhood-onset obesity.
CONCLUSIONS:
Severe childhood-onset obesity is associated with impaired Leydig cell function in young men and lower free testosterone may contribute to impaired skeletal characteristics.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
