A1 Refereed original research article in a scientific journal
Single nucleotide polymorphism rs11614913 associated with CC genotype in miR-196a2 is overrepresented in laryngeal squamous cell carcinoma, but not salivary gland tumors in Polish population
Authors: Marcin Skalski, Adam Ustaszewski, Katarzyna Jaskiewicz, Katarzyna Kiwerska, Malgorzata Wierzbicka, Hanna Klimza, Reidar Grenman, Maciej Giefing
Publisher: SPRINGER HEIDELBERG
Publication year: 2018
Journal: Journal of Applied Genetics
Journal name in source: JOURNAL OF APPLIED GENETICS
Journal acronym: J APPL GENET
Volume: 59
Issue: 3
First page : 301
Last page: 304
Number of pages: 4
ISSN: 1234-1983
eISSN: 2190-3883
DOI: https://doi.org/10.1007/s13353-018-0445-6
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/31857854
The miRNA-196a2 has shown significance in the development of various neoplasms, including head and neck squamous cell carcinoma (HNSCC). The oncogenic functionality of this miRNA is mediated via its potential to target annexin A1 mRNA, a tumor suppressor gene involved in inhibition of the NF-kappa B pathway. Interestingly, recent data indicate a susceptibility for aforementioned neoplasms in patients with the CC genotype vs the CT and TT genotypes of the rs11614913 SNP located within the DNA sequence of the miR-196a2 that results in elevated expression of the gene. To further investigate this phenomenon, we genotyped this SNP in 40 patients with laryngeal squamous cell carcinoma (LSCC), the most common tumor of the head and neck region and 60 patients with salivary gland tumors (SGT) that show a yet unexplained incidence increase in the last two decades. In agreement with previous reports, we have identified a statistically significant (p < 0.05) overrepresentation of the CC genotype in LSCC patients and demonstrated in LSCC cell lines that it results in elevated expression of miR-196a2 as compared to cell lines with the TT genotype of the respective SNP. Importantly, none of these correlations was found in patients with SGT. These findings underline the importance of the SNP rs11614913 for LSCC development in the Polish population and moreover highlight the different genetic background of the two studied neoplasms of the head and neck region.
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