A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The Cu2+-promoted cleavage of mRNA 5 '-cap analogs: A kinetic study with P-1-(7-methylguanosin-5 '-yl) P-3-(nucleosid-5 '-yl) triphospates and P-1-(7-methylguanosin-5 '-yl) P-4-(guanosin-5 '-yl) tetraphosphate
Tekijät: Wieczorek Z, Darzynkiewicz E, Kuusela S, Lonnberg H
Kustantaja: MARCEL DEKKER INC
Julkaisuvuosi: 1999
Journal: Nucleosides & nucleotides
Tietokannassa oleva lehden nimi: NUCLEOSIDES & NUCLEOTIDES
Lehden akronyymi: NUCLEOS NUCLEOT
Vuosikerta: 18
Numero: 1
Aloitussivu: 11
Lopetussivu: 21
Sivujen määrä: 11
ISSN: 0732-8311
DOI: https://doi.org/10.1080/07328319908045590
Tiivistelmä
A kinetic study on the cleavage of a number of mRNA 5'-cap analogs, m(7)GpppN and m(7)GppppG, with Cu2+ aquo ion has been performed. Time-dependent product distributions at various pH and metal ion concentrations have been determined by capillary zone electrophoresis, and these data have been used to calculate the rate constants for various parallel reactions of the breakdown of the cap analogs.
A kinetic study on the cleavage of a number of mRNA 5'-cap analogs, m(7)GpppN and m(7)GppppG, with Cu2+ aquo ion has been performed. Time-dependent product distributions at various pH and metal ion concentrations have been determined by capillary zone electrophoresis, and these data have been used to calculate the rate constants for various parallel reactions of the breakdown of the cap analogs.
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