A1 Refereed original research article in a scientific journal
The Cu2+-promoted cleavage of mRNA 5 '-cap analogs: A kinetic study with P-1-(7-methylguanosin-5 '-yl) P-3-(nucleosid-5 '-yl) triphospates and P-1-(7-methylguanosin-5 '-yl) P-4-(guanosin-5 '-yl) tetraphosphate
Authors: Wieczorek Z, Darzynkiewicz E, Kuusela S, Lonnberg H
Publisher: MARCEL DEKKER INC
Publication year: 1999
Journal: Nucleosides & nucleotides
Journal name in source: NUCLEOSIDES & NUCLEOTIDES
Journal acronym: NUCLEOS NUCLEOT
Volume: 18
Issue: 1
First page : 11
Last page: 21
Number of pages: 11
ISSN: 0732-8311
DOI: https://doi.org/10.1080/07328319908045590
Abstract
A kinetic study on the cleavage of a number of mRNA 5'-cap analogs, m(7)GpppN and m(7)GppppG, with Cu2+ aquo ion has been performed. Time-dependent product distributions at various pH and metal ion concentrations have been determined by capillary zone electrophoresis, and these data have been used to calculate the rate constants for various parallel reactions of the breakdown of the cap analogs.
A kinetic study on the cleavage of a number of mRNA 5'-cap analogs, m(7)GpppN and m(7)GppppG, with Cu2+ aquo ion has been performed. Time-dependent product distributions at various pH and metal ion concentrations have been determined by capillary zone electrophoresis, and these data have been used to calculate the rate constants for various parallel reactions of the breakdown of the cap analogs.
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