A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Surveillance of Circulating Bordetella pertussis Strains in Europe during 1998 to 2015
Tekijät: Barkoff AM, Mertsola J, Pierard D, Dalby T, Hoegh SV, Guillot S, Stefanelli P, van Gent M, Berbers G, Vestrheim DF, Greve-Isdahl M, Wehlin L, Ljungman M, Fry NK, Markey K, Auranen K, He QS, He QS
Kustantaja: AMER SOC MICROBIOLOGY
Julkaisuvuosi: 2018
Journal: Journal of Clinical Microbiology
Tietokannassa oleva lehden nimi: JOURNAL OF CLINICAL MICROBIOLOGY
Lehden akronyymi: J CLIN MICROBIOL
Artikkelin numero: UNSP e01998-17
Vuosikerta: 56
Numero: 5
Sivujen määrä: 12
ISSN: 0095-1137
DOI: https://doi.org/10.1128/JCM.01998-17
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/31590375
One reason for increased pertussis incidence is the adaptation of Bordetella pertussis to vaccine-induced immunity by modulating its genomic structure. This study, EUpert IV, includes 265 isolates collected from nine European countries during 2012 to 2015 (n = 265) and compares the results to previous EUpert I to III studies (1998 to 2009). The analyses included genotyping, serotyping, pulsed-field gel electrophoresis (PFGE), and multilocus variable-number tandem-repeat analysis (MLVA). Genotyping results showed only small variations among the common virulence genes of B. pertussis. The frequencies of serotypes Fim2 and Fim3 varied among the four collections. Genomic analyses showed that MLVA type 27 increased to 80% between the periods of 1998 to 2001 and 2012 to 2015. Two PFGE profiles, BpSR3 (29.4%) and BpSR10 (27.2%), constituted more than 50% of the circulating isolates in the present collection. Our study indicates that the European B. pertussis population is changing and became more homogenous after the introduction of acellular pertussis vaccines.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
