Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: A positron emission tomography study



: Tuunanen H, Kuusisto J, Toikka J, Jaaskelaeinen P, Marjamaki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J

Publisher: MOSBY-ELSEVIER

: 2007

: Journal of Nuclear Cardiology

: JOURNAL OF NUCLEAR CARDIOLOGY

: J NUCL CARDIOL

: 14

: 3

: 354

: 365

: 12

: 1071-3581

DOI: https://doi.org/10.1016/j.nuclcard.2006.12.329


Conclusions. In HCM attributable to the Asp175Asn mutation in the a-tropomyosin gene, myocardial oxidative metabolism and FFA metabolism are increased and inversely related to LV hypertrophy at both the whole heart and regional level. Increased metabolism and efficiency characterize patients with mild myocardial hypertrophy. These hypermetabolic alterations regress with advanced hypertrophy.




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