A1 Refereed original research article in a scientific journal

Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: A positron emission tomography study




AuthorsTuunanen H, Kuusisto J, Toikka J, Jaaskelaeinen P, Marjamaki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J

PublisherMOSBY-ELSEVIER

Publication year2007

JournalJournal of Nuclear Cardiology

Journal name in sourceJOURNAL OF NUCLEAR CARDIOLOGY

Journal acronymJ NUCL CARDIOL

Volume14

Issue3

First page 354

Last page365

Number of pages12

ISSN1071-3581

DOIhttps://doi.org/10.1016/j.nuclcard.2006.12.329(external)


Abstract

Conclusions. In HCM attributable to the Asp175Asn mutation in the a-tropomyosin gene, myocardial oxidative metabolism and FFA metabolism are increased and inversely related to LV hypertrophy at both the whole heart and regional level. Increased metabolism and efficiency characterize patients with mild myocardial hypertrophy. These hypermetabolic alterations regress with advanced hypertrophy.




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