A1 Refereed original research article in a scientific journal
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: A positron emission tomography study
Authors: Tuunanen H, Kuusisto J, Toikka J, Jaaskelaeinen P, Marjamaki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J
Publisher: MOSBY-ELSEVIER
Publication year: 2007
Journal: Journal of Nuclear Cardiology
Journal name in source: JOURNAL OF NUCLEAR CARDIOLOGY
Journal acronym: J NUCL CARDIOL
Volume: 14
Issue: 3
First page : 354
Last page: 365
Number of pages: 12
ISSN: 1071-3581
DOI: https://doi.org/10.1016/j.nuclcard.2006.12.329(external)
Conclusions. In HCM attributable to the Asp175Asn mutation in the a-tropomyosin gene, myocardial oxidative metabolism and FFA metabolism are increased and inversely related to LV hypertrophy at both the whole heart and regional level. Increased metabolism and efficiency characterize patients with mild myocardial hypertrophy. These hypermetabolic alterations regress with advanced hypertrophy.