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Synthesis of phosphate-branched oligonucleotides
Tekijät: Heinonen P, Lonnberg H
Kustantaja: AMER CHEMICAL SOC
Julkaisuvuosi: 2004
Lehti:: Bioconjugate Chemistry
Tietokannassa oleva lehden nimi: BIOCONJUGATE CHEMISTRY
Lehden akronyymi: BIOCONJUGATE CHEM
Vuosikerta: 15
Numero: 6
Aloitussivu: 1158
Lopetussivu: 1160
Sivujen määrä: 3
ISSN: 1043-1802
DOI: https://doi.org/10.1021/bc049845g
Tiivistelmä
A solid-phase synthesis for phosphate-branched oligonucleotides is described. The method is based on coupling of a single nucleoside phosphorodiamidite to terminal hydroxyl functions of two solid-supported oligonucleotides. After oxidation of the phosphite triester obtained to a phosphate triester, the third branch is assembled by conventional phosphoramidite chemistry.
A solid-phase synthesis for phosphate-branched oligonucleotides is described. The method is based on coupling of a single nucleoside phosphorodiamidite to terminal hydroxyl functions of two solid-supported oligonucleotides. After oxidation of the phosphite triester obtained to a phosphate triester, the third branch is assembled by conventional phosphoramidite chemistry.
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