A1 Refereed original research article in a scientific journal
Synthesis of phosphate-branched oligonucleotides
Authors: Heinonen P, Lonnberg H
Publisher: AMER CHEMICAL SOC
Publication year: 2004
Journal:: Bioconjugate Chemistry
Journal name in source: BIOCONJUGATE CHEMISTRY
Journal acronym: BIOCONJUGATE CHEM
Volume: 15
Issue: 6
First page : 1158
Last page: 1160
Number of pages: 3
ISSN: 1043-1802
DOI: https://doi.org/10.1021/bc049845g
Abstract
A solid-phase synthesis for phosphate-branched oligonucleotides is described. The method is based on coupling of a single nucleoside phosphorodiamidite to terminal hydroxyl functions of two solid-supported oligonucleotides. After oxidation of the phosphite triester obtained to a phosphate triester, the third branch is assembled by conventional phosphoramidite chemistry.
A solid-phase synthesis for phosphate-branched oligonucleotides is described. The method is based on coupling of a single nucleoside phosphorodiamidite to terminal hydroxyl functions of two solid-supported oligonucleotides. After oxidation of the phosphite triester obtained to a phosphate triester, the third branch is assembled by conventional phosphoramidite chemistry.
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