A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Identification of miR-193b Targets in Breast Cancer Cells and Systems Biological Analysis of Their Functional Impact
Tekijät: Leivonen SK, Rokka A, Ostling P, Kohonen P, Corthals GL, Kallioniemi O, Perälä M
Kustantaja: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Julkaisuvuosi: 2011
Lehti:: Molecular and Cellular Proteomics
Tietokannassa oleva lehden nimi: MOLECULAR & CELLULAR PROTEOMICS
Lehden akronyymi: MOL CELL PROTEOMICS
Numero sarjassa: 7
Vuosikerta: 10
Numero: 7
Sivujen määrä: 9
ISSN: 1535-9476
DOI: https://doi.org/10.1074/mcp.M110.005322
Verkko-osoite: http://dx.doi.org/10.1074/mcp.M110.005322
Tiivistelmä
In conclusion, we present here a proteomic screen to identify targets of miR-193b, and a systems biological approach to mimic its effects at the level of cellular phenotypes. This led to the identification of multiple genes whose combinatorial knock-down likely mediates the strong anti-cancer effects observed for miR-193b in breast cancer cells. Molecular & Cellular Proteomics 10: 10.1074/mcp.M110.005322, 1-9, 2011.
In conclusion, we present here a proteomic screen to identify targets of miR-193b, and a systems biological approach to mimic its effects at the level of cellular phenotypes. This led to the identification of multiple genes whose combinatorial knock-down likely mediates the strong anti-cancer effects observed for miR-193b in breast cancer cells. Molecular & Cellular Proteomics 10: 10.1074/mcp.M110.005322, 1-9, 2011.
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