Identification of miR-193b Targets in Breast Cancer Cells and Systems Biological Analysis of Their Functional Impact



: Leivonen SK, Rokka A, Ostling P, Kohonen P, Corthals GL, Kallioniemi O, Perälä M

: 2011

 Molecular and Cellular Proteomics

: MOLECULAR & CELLULAR PROTEOMICS

: MOL CELL PROTEOMICS

: 7

: 10

: 7

: 9

: 1535-9476

DOI: https://doi.org/10.1074/mcp.M110.005322

: http://dx.doi.org/10.1074/mcp.M110.005322


In conclusion, we present here a proteomic screen to identify targets of miR-193b, and a systems biological approach to mimic its effects at the level of cellular phenotypes. This led to the identification of multiple genes whose combinatorial knock-down likely mediates the strong anti-cancer effects observed for miR-193b in breast cancer cells. Molecular & Cellular Proteomics 10: 10.1074/mcp.M110.005322, 1-9, 2011.



Last updated on 26/11/2024 01:07:32 PM