Negative C-11-PIB PET Predicts Lack of Alzheimer's Disease Pathology in Postmortem Examination
: Noora M. Scheinin, Maria Gardberg, Matias Röyttä, Juha O. Rinne
Publisher: IOS PRESS
: 2018
: Journal of Alzheimer's Disease
: JOURNAL OF ALZHEIMERS DISEASE
: J ALZHEIMERS DIS
: 63
: 1
: 79
: 85
: 7
: 1387-2877
DOI: https://doi.org/10.3233/JAD-170569
: https://research.utu.fi/converis/portal/detail/Publication/31093246
Our aim was to assess whether in vivo C-11-PIB negative memory-impaired subjects may nonetheless exhibit brain Alzheimer's disease (AD) pathology. We re-evaluated the PET images and systematically characterized the postmortem neuropathology of six individuals who had undergone clinically indicated amyloid PET. The single case with negligible amyloid-beta (A beta) pathology had Lewy body disease, where concomitant AD changes are often seen. Further, the subject's plaques were predominantly diffuse. The predictive value of a negative C-11-PIB scan appears to be good, even in memory-impaired populations. Our results suggest that considerable neuritic A beta plaque pathology in the absence of specific/cortical C-11-PIB binding upon PET is unlikely.
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