A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
mu-opioid receptor system mediates reward processing in humans
Tekijät: Lauri Nummenmaa, Tiina Saanijoki, Lauri Tuominen, Jussi Hirvonen, Jetro J. Tuulari, Pirjo Nuutila, Kari Kalliokoski
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2018
Journal: Nature Communications
Tietokannassa oleva lehden nimi: NATURE COMMUNICATIONS
Lehden akronyymi: NAT COMMUN
Artikkelin numero: ARTN 1500
Vuosikerta: 9
Sivujen määrä: 7
ISSN: 2041-1723
eISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-03848-y
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/30928683
The endogenous mu-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [C-11] carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
