A1 Refereed original research article in a scientific journal

Nitric oxide-releasing porous silicon nanoparticles




AuthorsKafshgari MH, Cavallaro A, Delalat B, Harding FJ, McInnes SJP, Makila E, Salonen J, Vasilev K, Voelcker NH

PublisherSPRINGER

Publication year2014

JournalNanoscale Research Letters

Journal name in sourceNANOSCALE RESEARCH LETTERS

Journal acronymNANOSCALE RES LETT

Article number333

Volume9

Number of pages9

ISSN1556-276X

DOIhttps://doi.org/10.1186/1556-276X-9-333(external)

Web address http://www.nanoscalereslett.com/content/9/1/333(external)


Abstract

In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of D-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.




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