A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Double-Blind Randomized Placebo Controlled Trial Demonstrating Serum Cholesterol Lowering Efficacy of a Smoothie Drink with Added Plant Stanol Esters in an Indonesian Population
Tekijät: Lanny Lestiani, Dian Novita Chandra, Kirsi Laitinen, Fransisca Diah Ambarwati, Päivi Kuusisto, Widjaja Lukito
Kustantaja: HINDAWI LTD
Julkaisuvuosi: 2018
Journal: Cholesterol
Tietokannassa oleva lehden nimi: CHOLESTEROL
Lehden akronyymi: CHOLESTEROL
Artikkelin numero: ARTN 4857473
Sivujen määrä: 9
ISSN: 2090-1283
eISSN: 2090-1291
DOI: https://doi.org/10.1155/2018/4857473
Verkko-osoite: https://www.hindawi.com/journals/cholesterol/2018/4857473/
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/30542607
Indonesians have a high intake of saturated fats, a key contributing dietary factor to elevated blood cholesterol concentrations. We investigated the cholesterol lowering efficacy of a smoothie drink with 2 grams of plant stanols as esters to lower serum total and LDL-cholesterol concentrations in hypercholesterolemic Indonesian adults. The double-blind randomized placebo controlled parallel design study involved 99 subjects. Fifty subjects received control drink and dietary advice, and 49 subjects received intervention drink (Nutrive Benecol (R)) and dietary advice. Baseline, midline (week 2), and endline (week 4) assessments were undertaken for clinical, anthropometric, and biochemical variables. Compared to control, the smoothie drink with plant stanols reduced serum LDL-cholesterol concentration by 7.6% (p < 0.05) and 9.0% (p < 0.05) in two and four weeks, respectively. Serum total cholesterol was reduced by 5.7% (p < 0.05 compared to control) in two weeks, and no further reduction was detected after four weeks (5.6%). Compared to baseline habitual diet, LDL-cholesterol was reduced by 9.3% (p < 0.05) and 9.8% (p < 0.05) in the plant stanol ester group in two and four weeks, respectively. We conclude that consumption of smoothie drink with added plant stanol esters effectively reduces serum total and LDL-cholesterol of hypercholesterolemic Indonesian subjects already in two weeks.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
