A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Home-measured blood pressure is more strongly associated with atherosclerosis than clinic blood pressure: the Finn-HOME Study
Tekijät: Niiranen T, Jula A, Kantola I, Moilanen L, Kahonen M, Kesaniemi YA, Nieminen MS, Reunanen A
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2007
Journal: Journal of Hypertension
Tietokannassa oleva lehden nimi: JOURNAL OF HYPERTENSION
Lehden akronyymi: J HYPERTENS
Vuosikerta: 25
Numero: 6
Aloitussivu: 1225
Lopetussivu: 1231
Sivujen määrä: 7
ISSN: 0263-6352
DOI: https://doi.org/10.1097/HJH.0b013e3280d94336
Tiivistelmä
Background The aim of this study was to assess whether carotid intima-media thickness (IMT) is more strongly associated with home-measured blood pressure (BP) than clinic BP. Other risk factors associated with carotid atherosclerosis were also investigated.Methods We studied a representative unselected sample of the Finnish adult population (758 subjects aged 45-74 years). Subjects included in the study underwent a clinical interview, carotid ultrasonography, and measurement of clinic BP (mean of two measurements using a mercury sphygmomanometer) and home BP (mean of 14 duplicate measurements during 1 week using a validated, automatic device). Fasting blood samples for serum lipids and glucose were drawn.Results The Pearson correlation coefficients for carotid IMT and home/clinic BP differed significantly in favour of home measurement for systolic BP (0.34 versus 0.25, P<0.001), diastolic BP (0.20 versus 0.07, P<0.001) and pulse pressure (0.37 versus 0.27, P<0.001). In a linear regression model (R-2 = 0.32, P< 0.001), age (P< 0.001), home systolic BP (P = 0.002), serum triglycerides (P = 0.006), male sex (P = 0.009), smoking (P = 0.017), diabetes (P = 0.035), and low-density lipoprotein cholesterol (P = 0.041) were independently associated with increased IMT. The association between home BP and carotid IMT did not increase with the number of home measurements.Conclusion BP is one of the most important factors in the pathogenesis of atherosclerosis. Home-measured BP is more strongly associated with carotid atherosclerosis than clinic BP, even for a low number of measurements. These data support the application of home BP measurement in clinical practice.
Background The aim of this study was to assess whether carotid intima-media thickness (IMT) is more strongly associated with home-measured blood pressure (BP) than clinic BP. Other risk factors associated with carotid atherosclerosis were also investigated.Methods We studied a representative unselected sample of the Finnish adult population (758 subjects aged 45-74 years). Subjects included in the study underwent a clinical interview, carotid ultrasonography, and measurement of clinic BP (mean of two measurements using a mercury sphygmomanometer) and home BP (mean of 14 duplicate measurements during 1 week using a validated, automatic device). Fasting blood samples for serum lipids and glucose were drawn.Results The Pearson correlation coefficients for carotid IMT and home/clinic BP differed significantly in favour of home measurement for systolic BP (0.34 versus 0.25, P<0.001), diastolic BP (0.20 versus 0.07, P<0.001) and pulse pressure (0.37 versus 0.27, P<0.001). In a linear regression model (R-2 = 0.32, P< 0.001), age (P< 0.001), home systolic BP (P = 0.002), serum triglycerides (P = 0.006), male sex (P = 0.009), smoking (P = 0.017), diabetes (P = 0.035), and low-density lipoprotein cholesterol (P = 0.041) were independently associated with increased IMT. The association between home BP and carotid IMT did not increase with the number of home measurements.Conclusion BP is one of the most important factors in the pathogenesis of atherosclerosis. Home-measured BP is more strongly associated with carotid atherosclerosis than clinic BP, even for a low number of measurements. These data support the application of home BP measurement in clinical practice.
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