A1 Refereed original research article in a scientific journal
Home-measured blood pressure is more strongly associated with atherosclerosis than clinic blood pressure: the Finn-HOME Study
Authors: Niiranen T, Jula A, Kantola I, Moilanen L, Kahonen M, Kesaniemi YA, Nieminen MS, Reunanen A
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2007
Journal: Journal of Hypertension
Journal name in source: JOURNAL OF HYPERTENSION
Journal acronym: J HYPERTENS
Volume: 25
Issue: 6
First page : 1225
Last page: 1231
Number of pages: 7
ISSN: 0263-6352
DOI: https://doi.org/10.1097/HJH.0b013e3280d94336
Abstract
Background The aim of this study was to assess whether carotid intima-media thickness (IMT) is more strongly associated with home-measured blood pressure (BP) than clinic BP. Other risk factors associated with carotid atherosclerosis were also investigated.Methods We studied a representative unselected sample of the Finnish adult population (758 subjects aged 45-74 years). Subjects included in the study underwent a clinical interview, carotid ultrasonography, and measurement of clinic BP (mean of two measurements using a mercury sphygmomanometer) and home BP (mean of 14 duplicate measurements during 1 week using a validated, automatic device). Fasting blood samples for serum lipids and glucose were drawn.Results The Pearson correlation coefficients for carotid IMT and home/clinic BP differed significantly in favour of home measurement for systolic BP (0.34 versus 0.25, P<0.001), diastolic BP (0.20 versus 0.07, P<0.001) and pulse pressure (0.37 versus 0.27, P<0.001). In a linear regression model (R-2 = 0.32, P< 0.001), age (P< 0.001), home systolic BP (P = 0.002), serum triglycerides (P = 0.006), male sex (P = 0.009), smoking (P = 0.017), diabetes (P = 0.035), and low-density lipoprotein cholesterol (P = 0.041) were independently associated with increased IMT. The association between home BP and carotid IMT did not increase with the number of home measurements.Conclusion BP is one of the most important factors in the pathogenesis of atherosclerosis. Home-measured BP is more strongly associated with carotid atherosclerosis than clinic BP, even for a low number of measurements. These data support the application of home BP measurement in clinical practice.
Background The aim of this study was to assess whether carotid intima-media thickness (IMT) is more strongly associated with home-measured blood pressure (BP) than clinic BP. Other risk factors associated with carotid atherosclerosis were also investigated.Methods We studied a representative unselected sample of the Finnish adult population (758 subjects aged 45-74 years). Subjects included in the study underwent a clinical interview, carotid ultrasonography, and measurement of clinic BP (mean of two measurements using a mercury sphygmomanometer) and home BP (mean of 14 duplicate measurements during 1 week using a validated, automatic device). Fasting blood samples for serum lipids and glucose were drawn.Results The Pearson correlation coefficients for carotid IMT and home/clinic BP differed significantly in favour of home measurement for systolic BP (0.34 versus 0.25, P<0.001), diastolic BP (0.20 versus 0.07, P<0.001) and pulse pressure (0.37 versus 0.27, P<0.001). In a linear regression model (R-2 = 0.32, P< 0.001), age (P< 0.001), home systolic BP (P = 0.002), serum triglycerides (P = 0.006), male sex (P = 0.009), smoking (P = 0.017), diabetes (P = 0.035), and low-density lipoprotein cholesterol (P = 0.041) were independently associated with increased IMT. The association between home BP and carotid IMT did not increase with the number of home measurements.Conclusion BP is one of the most important factors in the pathogenesis of atherosclerosis. Home-measured BP is more strongly associated with carotid atherosclerosis than clinic BP, even for a low number of measurements. These data support the application of home BP measurement in clinical practice.
UTU Research Portal