Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

Tekijät: Acevedo N, Reinius LE, Vitezic M, Fortino V, Soderhall C, Honkanen H, Veijola R, Simell O, Toppari J, Ilonen J, Knip M, Scheynius A, Hyoty H, Greco D, Kere J

Kustantaja: BIOMED CENTRAL LTD

Julkaisuvuosi: 2015

Journal: Clinical Epigenetics

Tietokannassa oleva lehden nimi: CLINICAL EPIGENETICS

Lehden akronyymi: CLIN EPIGENETICS

Artikkelin numero: ARTN 34

Vuosikerta: 7

Sivujen määrä: 20

ISSN: 1868-7083

DOI: https://doi.org/10.1186/s13148-015-0064-6

Tiivistelmä

Conclusions: This study reveals that susceptibility loci for complex inflammatory diseases (for example, IRF5, NOD2, and PTGER4) and genes encoding histone modifiers and chromatin remodeling factors (for example, HDAC4, KDM2A, KDM2B, JARID2, ARID3A, and SMARCD3) undergo DNA methylation changes in leukocytes during early childhood. These results open new perspectives to understand leukocyte maturation and provide a catalogue of CpG sites that may need to be corrected for age effects when performing DNA methylation studies in children.