Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes - UTU Research Portal

A1 Refereed original research article in a scientific journal

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

Authors: Acevedo N, Reinius LE, Vitezic M, Fortino V, Soderhall C, Honkanen H, Veijola R, Simell O, Toppari J, Ilonen J, Knip M, Scheynius A, Hyoty H, Greco D, Kere J

Publisher: BIOMED CENTRAL LTD

Publication year: 2015

Journal: Clinical Epigenetics

Journal name in source: CLINICAL EPIGENETICS

Journal acronym: CLIN EPIGENETICS

Article number: ARTN 34

Volume: 7

Number of pages: 20

ISSN: 1868-7083

DOI: https://doi.org/10.1186/s13148-015-0064-6

Abstract

Conclusions: This study reveals that susceptibility loci for complex inflammatory diseases (for example, IRF5, NOD2, and PTGER4) and genes encoding histone modifiers and chromatin remodeling factors (for example, HDAC4, KDM2A, KDM2B, JARID2, ARID3A, and SMARCD3) undergo DNA methylation changes in leukocytes during early childhood. These results open new perspectives to understand leukocyte maturation and provide a catalogue of CpG sites that may need to be corrected for age effects when performing DNA methylation studies in children.