Azole antimycotics and drug interactions in the perioperative period

: Saari TI, Olkkola KT

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2010

Current Opinion in Anaesthesiology

: CURRENT OPINION IN ANESTHESIOLOGY

: CURR OPIN ANESTHESIO

: 4

: 23

: 4

: 441

: 448

: 8

: 0952-7907

DOI: https://doi.org/10.1097/ACO.0b013e32833a254d

This review focuses on azole antimycotics and anesthetic drugs being used during the perioperative period and discusses the possible clinically significant drug-drug interactions. Azole antimycotics are amongst the strongest inhibitors of CYP-mediated drug metabolism. Anesthesiologists must be aware of the interaction potential of azole antimycotics to be able to adjust their perioperative strategies according to the patient's condition and concomitant medication.

azoles, benzodiazepines, drug interactions, intravenous hypnotics, opioid, pharmacokinetics

Surgery, anesthesiology, intensive care, radiology