Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality



: Seppala I, Kleber ME, Lyytikainen LP, Hernesniemi JA, Makela KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kahonen N, Alfthan G, Viikari JSA, Kahonen M, Raitakari OT, Marz W, Meinitzer A, Lehtimaki T

Publisher: OXFORD UNIV PRESS

: 2014

 European Heart Journal

: EUROPEAN HEART JOURNAL

: EUR HEART J

: 35

: 8

: 524

: 531

: 8

: 0195-668X

DOI: https://doi.org/10.1093/eurheartj/eht447


Conclusions AGXT2 has an important role in SDMA metabolism in humans. AGXT2 may additionally have an unanticipated role in the autonomic nervous system regulation of cardiac function.


Asymmetric dimethylarginine, Genetics, Genome-wide association study, Heart rate variability, Mortality, Sudden cardiac death, Symmetric dimethylarginine



Last updated on 26/11/2024 06:16:18 PM