Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality
: Seppala I, Kleber ME, Lyytikainen LP, Hernesniemi JA, Makela KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kahonen N, Alfthan G, Viikari JSA, Kahonen M, Raitakari OT, Marz W, Meinitzer A, Lehtimaki T
Publisher: OXFORD UNIV PRESS
: 2014
: European Heart Journal
: EUROPEAN HEART JOURNAL
: EUR HEART J
: 35
: 8
: 524
: 531
: 8
: 0195-668X
DOI: https://doi.org/10.1093/eurheartj/eht447
Conclusions AGXT2 has an important role in SDMA metabolism in humans. AGXT2 may additionally have an unanticipated role in the autonomic nervous system regulation of cardiac function.