Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality - UTU Research Portal

A1 Refereed original research article in a scientific journal

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality

Authors: Seppala I, Kleber ME, Lyytikainen LP, Hernesniemi JA, Makela KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kahonen N, Alfthan G, Viikari JSA, Kahonen M, Raitakari OT, Marz W, Meinitzer A, Lehtimaki T

Publisher: OXFORD UNIV PRESS

Publication year: 2014

Journal: European Heart Journal

Journal name in source: EUROPEAN HEART JOURNAL

Journal acronym: EUR HEART J

Volume: 35

Issue: 8

First page : 524

Last page: 531

Number of pages: 8

ISSN: 0195-668X

DOI: https://doi.org/10.1093/eurheartj/eht447

Abstract

Conclusions AGXT2 has an important role in SDMA metabolism in humans. AGXT2 may additionally have an unanticipated role in the autonomic nervous system regulation of cardiac function.