Knowledge of the full target space of bioactive substances, approved and
investigational drugs as well as chemical probes, provides important
insights into therapeutic potential and possible adverse effects. The
existing compound-target bioactivity data resources are often
incomparable due to non-standardized and heterogeneous assay types and
variability in endpoint measurements. To extract higher value from the
existing and future compound target-profiling data, we implemented an
open-data web platform, named Drug Target Commons (DTC), which features
tools for crowd-sourced compound-target bioactivity data annotation,
standardization, curation, and intra-resource integration. We
demonstrate the unique value of DTC with several examples related to
both drug discovery and drug repurposing applications and invite
researchers to join this community effort to increase the reuse and
extension of compound bioactivity data