A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Tekijät: Jing Tang, Zia-ur-Rehman, Balaguru Raviku, Zaid Alam, Anni Rebane, Markus Vähä-Koskela, Gopal Peddinti, Arjan J. van drichem, Janica Wakkinen, Alok Jaiswal, Ella Karjalainen, Prson Gautam, Liye He, Elina Parri, Suleiman Khan, Abhishekh Gupta, Mehreen Ali, Laxman Yetukuri, Anna-Lena Gustavsson, Brinton Seashore-Ludlow, Anne Hersey, Andrew R. Leach, John P. Overington, Gretchen Repasky, Krister Wennerberg, Tero Aittokallio
Kustantaja: Cell Press
Julkaisuvuosi: 2018
Journal: Cell Chemical Biology
Vuosikerta: 25
Numero: 2
Aloitussivu: 224
Lopetussivu: 229
Sivujen määrä: 8
ISSN: 2451-9448
eISSN: 2451-9448
DOI: https://doi.org/10.1016/j.chembiol.2017.11.009
Knowledge of the full target space of bioactive substances, approved and
investigational drugs as well as chemical probes, provides important
insights into therapeutic potential and possible adverse effects. The
existing compound-target bioactivity data resources are often
incomparable due to non-standardized and heterogeneous assay types and
variability in endpoint measurements. To extract higher value from the
existing and future compound target-profiling data, we implemented an
open-data web platform, named Drug Target Commons (DTC), which features
tools for crowd-sourced compound-target bioactivity data annotation,
standardization, curation, and intra-resource integration. We
demonstrate the unique value of DTC with several examples related to
both drug discovery and drug repurposing applications and invite
researchers to join this community effort to increase the reuse and
extension of compound bioactivity data
