A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia
Tekijät: Leslie Skeith, Marc Carrier, Risto Kaaja, Ida Martinelli, David Petroff, Ekkehard Schleußner, Carl A. Laskin, Marc A. Rodger
Kustantaja: American Society of Hematology
Julkaisuvuosi: 2016
Journal: Blood
Vuosikerta: 127
Numero: 13
Aloitussivu: 1650
Lopetussivu: 1655
Sivujen määrä: 6
ISSN: 0006-4971
eISSN: 1528-0020
DOI: https://doi.org/10.1182/blood-2015-12-626739
Abstract
We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19; P = .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia
