A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia - UTU Research Portal

A2 Refereed review article in a scientific journal

A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia

Authors: Leslie Skeith, Marc Carrier, Risto Kaaja, Ida Martinelli, David Petroff, Ekkehard Schleußner, Carl A. Laskin, Marc A. Rodger

Publisher: American Society of Hematology

Publication year: 2016

Journal: Blood

Volume: 127

Issue: 13

First page : 1650

Last page: 1655

Number of pages: 6

ISSN: 0006-4971

eISSN: 1528-0020

DOI: https://doi.org/10.1182/blood-2015-12-626739

Abstract

We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19; P = .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia