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The effect of base sequence on the hydrolytic stability of RNA phosphodiester bonds
Tekijät: Pentikainen U, Perakyla M, Lonnberg H
Julkaisuvuosi: 2005
Lehti:: Collection Symposium Series
Tietokannassa oleva lehden nimi: Chemistry of Nucleic Acid Components
Lehden akronyymi: COLL SYMPOS SERIES
Vuosikerta: 7
Aloitussivu: 259
Lopetussivu: 260
Sivujen määrä: 2
ISBN: 80-86241-25-4
Tiivistelmä
The hydrolytic stability of RNA phosphodiester bonds exhibit even more marked variation within random single strands than within loops or bulges. Molecular dynamics calculations have been applied to the initial state and to the transition state model, i.e. a sequence containing a phosphorane intermediate, to evaluate base-stacking as a factor affecting the cleavage rate.
The hydrolytic stability of RNA phosphodiester bonds exhibit even more marked variation within random single strands than within loops or bulges. Molecular dynamics calculations have been applied to the initial state and to the transition state model, i.e. a sequence containing a phosphorane intermediate, to evaluate base-stacking as a factor affecting the cleavage rate.
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