A1 Refereed original research article in a scientific journal
The effect of base sequence on the hydrolytic stability of RNA phosphodiester bonds
Authors: Pentikainen U, Perakyla M, Lonnberg H
Publication year: 2005
Journal:: Collection Symposium Series
Journal name in source: Chemistry of Nucleic Acid Components
Journal acronym: COLL SYMPOS SERIES
Volume: 7
First page : 259
Last page: 260
Number of pages: 2
ISBN: 80-86241-25-4
Abstract
The hydrolytic stability of RNA phosphodiester bonds exhibit even more marked variation within random single strands than within loops or bulges. Molecular dynamics calculations have been applied to the initial state and to the transition state model, i.e. a sequence containing a phosphorane intermediate, to evaluate base-stacking as a factor affecting the cleavage rate.
The hydrolytic stability of RNA phosphodiester bonds exhibit even more marked variation within random single strands than within loops or bulges. Molecular dynamics calculations have been applied to the initial state and to the transition state model, i.e. a sequence containing a phosphorane intermediate, to evaluate base-stacking as a factor affecting the cleavage rate.
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