B1 Non-refereed article in a scientific journal
Synthesis of oligonucleotide analogues by using phosphoramidite reagents derived from 2,2-bis(hydroxymethyl)malonates
Authors: Guzaev A, Salo H, Azhayev A, Lonnberg H
Publisher: INST ORGANIC CHEM AND BIOCHEM
Publication year: 1996
Journal:: Collection of Czechoslovak Chemical Communications
Journal name in source: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Journal acronym: COLLECT CZECH CHEM C
Volume: 61
First page : S226
Last page: S229
Number of pages: 4
ISSN: 0010-0765
Abstract
A new family of non-nucleosidic phospharamidite rt agents derived from either esters or amides of 2,2-bis(hydroxymethyl)malonic acid is described. The utility of the building blocks 1-5 ii demonstrated by preparation of 5'-phosphorylated oligonucleotides as well as hydrophobic, polyamino and fluorescent labelled oligonucleotide analogues.
A new family of non-nucleosidic phospharamidite rt agents derived from either esters or amides of 2,2-bis(hydroxymethyl)malonic acid is described. The utility of the building blocks 1-5 ii demonstrated by preparation of 5'-phosphorylated oligonucleotides as well as hydrophobic, polyamino and fluorescent labelled oligonucleotide analogues.
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