A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells
Tekijät: Glazova M, Aho TLT, Palmetshofer A, Murashov A, Scheinin M, Koskinen PJ
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2005
Journal: Molecular Brain Research
Tietokannassa oleva lehden nimi: MOLECULAR BRAIN RESEARCH
Lehden akronyymi: MOL BRAIN RES
Vuosikerta: 138
Numero: 2
Aloitussivu: 116
Lopetussivu: 123
Sivujen määrä: 8
ISSN: 0169-328X
DOI: https://doi.org/10.1016/j.molbrainres.2005.04.003
Tiivistelmä
The activity of NFAR family transcription factors is tightly regulated in T cells via signaling pathways initiated by stimulation of the T cell receptor or its downstream effectors such as the Pim-1 serine/threonine kinase. Here, we demonstrate that NFATc-dependent transcription is inducible also in NGF-differentiated rat PC12 pheochromocytoma cells treated with phorbol esthers, calcium ionophores and/or forskolin and that the Pim-1 kinase can further potentiate the effects of these agents. PC 12 cells, share many characteristics with sympathetic neurons and can be induced to produce and release catecholamines, such as dopamine and noradrenaline, and inflammatory cytokines, such as interleukin 6. Interestingly, Pim-1 can synergize with forskolin-induced signaling pathways to stimulate also neuroendocrine functions of PC12 cells. (c) 2005 Elsevier B.V. All rights reserved.
The activity of NFAR family transcription factors is tightly regulated in T cells via signaling pathways initiated by stimulation of the T cell receptor or its downstream effectors such as the Pim-1 serine/threonine kinase. Here, we demonstrate that NFATc-dependent transcription is inducible also in NGF-differentiated rat PC12 pheochromocytoma cells treated with phorbol esthers, calcium ionophores and/or forskolin and that the Pim-1 kinase can further potentiate the effects of these agents. PC 12 cells, share many characteristics with sympathetic neurons and can be induced to produce and release catecholamines, such as dopamine and noradrenaline, and inflammatory cytokines, such as interleukin 6. Interestingly, Pim-1 can synergize with forskolin-induced signaling pathways to stimulate also neuroendocrine functions of PC12 cells. (c) 2005 Elsevier B.V. All rights reserved.
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