The longevity of particulate filler composite (PFC) is uncertain in large restorations with high occlusal stresses. From a biomimetic point of view, the use of short fiber-reinforced composite (SFRC) as dentin replacing material appears a promising treatment strategy and may solve some potential problems associated with composite restoration in high stress-bearing areas. This chapter briefly presents the theoretical background, benefits and clinical applications of SFRC in dentistry. In this series of clinical cases an attempt was made by using SFRC (everX Posterior; GC Corporation, Tokyo, Japan) as dentine-replacing material or bulk base under surface layer of enamel-replacing PFC, i.e., biomimetic or bilayered composite restorations, in order to improve the load-bearing capacity and clinical longevity of resin-based composite restorations. Within the limitations of this case series of clinical indications, the presented restorative approach is a promising and cost efficient way to extend the indication range of direct and indirect resin composite restorations and gives the clinician alternative treatment options.