Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis



: Heinonen S, Jartti T, Garcia C, Oliva S, Smitherman C, Anguiano E, de Steenhuijsen Piters WA, Vuorinen T, Ruuskanen O, Dimo B, Suarez NM, Pascual V, Ramilo O, Mejias A.

: 2016

: American Journal of Respiratory and Critical Care Medicine

: 193

: 7

: 772

: 782

: 11

: 1073-449X

: 1535-4970

DOI: https://doi.org/10.1164/rccm.201504-0749OC


Conclusions: Symptomatic RV infection induced a robust and reproducible transcriptional signature, whereas identification of RV in asymptomatic children was not associated with significant systemic transcriptional immune responses. Transcriptional profiling represents a useful tool to discriminate between active infection and incidental virus detection.



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