A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
An Allosteric Receptor by Simultaneous "Casting" and "Molding" in a Dynamic Combinatorial Library
Tekijät: Li JW, Nowak P, Otto S
Kustantaja: WILEY-V C H VERLAG GMBH
Julkaisuvuosi: 2015
Journal: Angewandte Chemie International Edition
Tietokannassa oleva lehden nimi: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Lehden akronyymi: ANGEW CHEM INT EDIT
Vuosikerta: 54
Numero: 3
Aloitussivu: 833
Lopetussivu: 837
Sivujen määrä: 5
ISSN: 1433-7851
DOI: https://doi.org/10.1002/anie.201408907
Tiivistelmä
Allosteric synthetic receptors are difficult to access by design. Herein we report a dynamic combinatorial strategy towards such systems based on the simultaneous use of two different templates. Through a process of simultaneous casting (the assembly of a library member around a template) and molding (the assembly of a library member inside the binding pocket of a template), a Russian-doll-like termolecular complex was obtained with remarkable selectivity. Analysis of the stepwise formation of the complex indicates that binding of the two partners by the central macrocycle exhibits significant positive cooperativity. Such allosteric systems represent hubs that may have considerable potential in systems chemistry.
Allosteric synthetic receptors are difficult to access by design. Herein we report a dynamic combinatorial strategy towards such systems based on the simultaneous use of two different templates. Through a process of simultaneous casting (the assembly of a library member around a template) and molding (the assembly of a library member inside the binding pocket of a template), a Russian-doll-like termolecular complex was obtained with remarkable selectivity. Analysis of the stepwise formation of the complex indicates that binding of the two partners by the central macrocycle exhibits significant positive cooperativity. Such allosteric systems represent hubs that may have considerable potential in systems chemistry.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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