A1 Refereed original research article in a scientific journal
An Allosteric Receptor by Simultaneous "Casting" and "Molding" in a Dynamic Combinatorial Library
Authors: Li JW, Nowak P, Otto S
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2015
Journal: Angewandte Chemie International Edition
Journal name in source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Journal acronym: ANGEW CHEM INT EDIT
Volume: 54
Issue: 3
First page : 833
Last page: 837
Number of pages: 5
ISSN: 1433-7851
DOI: https://doi.org/10.1002/anie.201408907
Abstract
Allosteric synthetic receptors are difficult to access by design. Herein we report a dynamic combinatorial strategy towards such systems based on the simultaneous use of two different templates. Through a process of simultaneous casting (the assembly of a library member around a template) and molding (the assembly of a library member inside the binding pocket of a template), a Russian-doll-like termolecular complex was obtained with remarkable selectivity. Analysis of the stepwise formation of the complex indicates that binding of the two partners by the central macrocycle exhibits significant positive cooperativity. Such allosteric systems represent hubs that may have considerable potential in systems chemistry.
Allosteric synthetic receptors are difficult to access by design. Herein we report a dynamic combinatorial strategy towards such systems based on the simultaneous use of two different templates. Through a process of simultaneous casting (the assembly of a library member around a template) and molding (the assembly of a library member inside the binding pocket of a template), a Russian-doll-like termolecular complex was obtained with remarkable selectivity. Analysis of the stepwise formation of the complex indicates that binding of the two partners by the central macrocycle exhibits significant positive cooperativity. Such allosteric systems represent hubs that may have considerable potential in systems chemistry.
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